Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis

Howard Y. Chang, MD, PhD is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A. 2010; 107 (43):18475–18480. [PMC free article] [Google Scholar] Chu G, Chang E. Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Biogenesis and cellular fates of long non-coding RNAs. a | Biogenesis of long non-coding RNAs (lncRNAs). Unlike mRNAs, many RNA polymerase II (Pol II)-transcribed lncRNAs are inefficiently processed 4,5,113 and are retained in the nucleus 6,10,12,13,16 (mechanisms of lncRNA nuclear retention are shown in parts b–e), whereas others are spliced and exported to the cytoplasm.

2021.12.03 00:12 sburgess86 Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis

Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis submitted by sburgess86 to BiologyPreprints [link] [comments]

2021.12.03 00:12 ufosceptic I quit my job and wrote an r/antiwork theme song, “Nobody’s Working Fool”.

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2021.12.03 00:12 allenbyNY New Zealand

New Zealand submitted by allenbyNY to AHomeForPlagueRats [link] [comments]

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2021.12.03 00:12 TheDailyNick Win This Year's Top Holiday Wishlist Items with the 12 Days of Nick Jr. Holiday Sweepstakes

Win This Year's Top Holiday Wishlist Items with the 12 Days of Nick Jr. Holiday Sweepstakes submitted by TheDailyNick to NickBits [link] [comments]

2021.12.03 00:11 Sihnar Possible prelate fix. Might be useful for the devs.

Possible prelate fix. Might be useful for the devs. submitted by Sihnar to aoe4 [link] [comments]

2021.12.03 00:11 SoupEarthSociety Mister Rage

Mister Rage submitted by SoupEarthSociety to BoneAppleTea [link] [comments]

2021.12.03 00:11 fishmanisnice Finally coming back to YT

Finally coming back to YT submitted by fishmanisnice to SmallYoutubers [link] [comments]

2021.12.03 00:11 sburgess86 miR2Trait: an integrated resource for investigating miRNA-disease associations

miR2Trait: an integrated resource for investigating miRNA-disease associations submitted by sburgess86 to BiologyPreprints [link] [comments]

2021.12.03 00:11 PatientBalance I feel like I’m overthinking it this time around, 5 days in and something feels off

This is my second time around doing keto, I did it about a year and a half ago and loved it so much.
I’m 5’1 F SW:136 GW: 122. I just read in a few posts that you don’t become fat adaptive for a month or more. And for some reason even though I’ve done this before, it is freaking me out because I’m eating a ton of fat.
Secondly, I keep getting closer to 30 g of net carbs, but a lot of those are coming from green vegetables. Is that really going to set me back or keep me out of ketosis?
Thirdly, I am five days in and I’m not feeling any symptoms of ketosis or keto flu. I can’t smell my own breasts, my energy is up and down kind of all day, mostly up.
I’ve gone through the FAQ three times since learning about keto and if this wonderful community wouldn’t mind, I would just love some reassurance for my specific questions. If it helps, I’m also fasting at least 16 hours a day and counting calories, meticulously measuring everything I eat.
daily caloric goal is 1230 (I average this on a weekly basis)
Today I have 34 net carbs, weekly high, 111g of fat and 71g of protein.
Honestly would love any advice on what I’m doing right and what I could be doing differently.
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2021.12.03 00:11 jswp5 Pokémon supporters really out here arguing with a strand of DNA

Pokémon supporters really out here arguing with a strand of DNA submitted by jswp5 to Altrive [link] [comments]

2021.12.03 00:11 eriicksao24 🤤🤤

🤤🤤 submitted by eriicksao24 to AngieDiaz [link] [comments]

2021.12.03 00:11 Capital_Ad9574 Magic Internet Beans 🌱 Less than a week old with some nice steady growth! Experienced team behind this one, some great potential here! 🚀

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2021.12.03 00:11 sburgess86 A versatile new ubiquitin detection and purification tool derived from a bacterial deubiquitylase

A versatile new ubiquitin detection and purification tool derived from a bacterial deubiquitylase submitted by sburgess86 to BiologyPreprints [link] [comments]

2021.12.03 00:11 Neko_Shota Need help on making a decent pve team

Need help on making a decent pve team submitted by Neko_Shota to CookieRunKingdoms [link] [comments]

2021.12.03 00:11 putrefachan life fucking sucks

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2021.12.03 00:11 Professor6996 What’d you call a Grizzly with no teeth?

Gummy Bear
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2021.12.03 00:11 DeMappaussant I think it’s serious business here

I think it’s serious business here submitted by DeMappaussant to pics [link] [comments]

2021.12.03 00:11 EricLauber Seeking assistance to reverse engineer Jasco IoT product APIs

Hello! I feel like this post falls under multiple flair, but I can only pick one so Discussion it is. Hopefully this sort of post is allowed.
I have several Jasco (GE-branded) myTouchSmart switches at home. I bought these before I learned more about Home Automation and the advantages of self-hosting or some of the other platforms. Jasco lets you integrate their switches with Amazon Alexa or Google Home via their cloud services which are free (but for how long?). I thought it would be a fun project to try to reverse engineer both how the cloud services work, and how the switches themselves work. This may eventually lead to integrating with HomeAssistant or other products.
I've started a GitHub repository heredocumenting what I've found thus far, and am hosting it in an easier-to-read format using GitHub Pages here. I've only just started and haven't figured much out, and I would love some help from others who have been at this for a while. If you are in this space or are interested in helping, please do so on GitHub! Or if you don't have an account but want to post here, that's fine. I can update the repo.
I did check by the way, and the GE myTouchSmart In-Wall Switch is listed as unsupported on Tasmota's website.
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2021.12.03 00:11 littleshopofalchemy Offering readings

All topics welcome (: send a chat or message
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2021.12.03 00:11 tumamaselacome Algunos "memes" impresos que me encontre en una marcha contra la reforma educativa, Guadalajara (2013)

Algunos submitted by tumamaselacome to Mujico [link] [comments]

2021.12.03 00:11 Future-Thought-2304 Santacoin aims to reward those who will shake hands with BUSD.Santa_coin #busd

Santacoin aims to reward those who will shake hands with BUSD — which means, if you hold Santa Coin, you will receive BUSD prizes. I like this project very much. I am sure for the success of this project. Santa_coin #BSC #Binancechain #BTC #C_z #Shiba #evergrow #cryptomoonshots #busd
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2021.12.03 00:11 Cautious-Student1770 Irrational light rail hate

Canberra was built for the car. I hate that phrase, but Canberran's both utter and hear it all the time. Let's spend 30 seconds breaking down what that phrase actually means on the ground though. What is a city for? What does it do? Is a city a place for people of all walks of life? A place for business? A place to meet? Human interaction? A place for vibrancy to happen? A place for kids to be able to run around, explore nature, take part in culture and the arts (an official human right for children)... in a nutshell, is a city a place for people to be people or... is a city a place for people who want to drive cars?
A city can be somewhere built for people, or a place built for cars. It can't be both.
Surely we want to live in somewhere that's fun, vibrant, happy, enjoyable... not somewhere that a toddler is likely to be killed if they accidently wander into the public realm unsupervised for 30 seconds?
Apparently not though. Based on the submissions that people have sent into the NCA regarding the light rail 2A project so far. People are angry, irrationally so. They're angry because despite all of the known negative externalities surrounding a large population using their cars for every errand, these people want to continue driving their cars through the centre of a growing city, without any hinderance. They want to be able to drive at speeds that we know will kill vulnerable road users. They also don't want their vista's interrupted as they do so. It's an incredibly selfish attitude, an attitude that car manufacturers have spent 100 years normalising.
I've heard a lot of hate for light rail... but the most illogical hatred is "it will cause congestion". What people who say this mean is "I want to continue driving my car when I want, where I want, how I want and don't want to compromise." I assume these people are also the ones who aspire to arrive in Civic with 10,000 other people and be able to park right out the front of their destination. A nanosecond of critical thought reveals this is not possible. Anyway back to trams.
Here is a video demonstrating just how much space cars take up compared to other forms of transport... keep in mind in the video they're showing 5x trams with 40 people on board. Canberra's trams have a max capacity of 207.
The private motor vehicle is the most spatially intensive form of transport that humans have ever invented. The primary source of traffic congestion in cities is not mass transit projects, not bicycles, not pedestrians... it's too many people driving cars.
The space required by cars becomes even worse once vehicles are moving.
Picture a 33 metre long tram at approx half capacity (102 people) moving at 70 km/h. Allowing for a 10 second safety gap, that tram is taking up 230 metres x 3.5 metres of space.
Now picture those 102 people in 85 cars (average of 1.2 people per car, typical for Canberra). The 3 most popular cars currently sold in Australia are the Hilux, Ranger and RAV4. The average length of these cars are 5 metres. For cars, a recommended safety gap at 70 km/h is 2 seconds, or 39 metres. To consistently roll along at 70 km/h with a recommended safety gap, those cars would occupy 3.73 km x 3.5 metres of lane space.
Let's do it with a tram at full capacity, 204 people. The tram still takes up 230 metres. But in cars, with an average of 1.2 people per private car, 204 people now take up 7.46 km if rolling along at 70 km/h. That's the distance from the Civic light rail stop to Mitchell.
I'm sure there's been some who have watched the above video and thought that widening the road would allow more cars to get through faster... yes... this is the logic used by politicians and traffic engineers for the last few decades. But widening road space wont fix it permanently... that will just make driving more appealing to more people, who will then start driving cars themselves, resulting in congestion returning (induced demand). Despite obscene amounts of money being spent on road networks worldwide since the 1950's no city in the world has ever built its way out of traffic congestion. It does not work.
The following ways have been proven to reduce traffic congestion though;

Which one of these sounds most appealing? Surely we don't want $50 pay parking on top of congestion charging?
Anyway, vent nearly over. If you hear someone passionately ranting about how Canberra's light rail doesn't make sense, spit flying in every direction, ask them what should be done instead? What should Canberra's transport systems look like when we hit a million people in under 100 years? What kind of city do we want for our kids and grand kids? Do we keep growing out? Hostile take over of Queanbeyan? Bulldoze Canberra's original suburbs to make Canberra and Adelaide Avenues 10 lanes each way? If we continue with the status quo, where do we put all the cars when they're not in use? Underground is too expensive. We have a housing affordability crisis as it is, and underground car parks can add $50,000 per space to the cost of a home. That's not fair. High rise car parks? Apparently high rise residential towers are blasphemous in this city, I cant imagine high rise car parks would be popular.
Shared autonomous vehicles and swarming aren't going to be an appropriate solution for a city either. Doubly so now that there's talk of pedestrians and cyclists being forced to wear beacons so that AV's can operate faster. What a dystopian nightmare.
Pollution is also a problem... while EV's will reduce tailpipe emissions within cities, when the additional weight of batteries is taken into account, the particulate matter emitted from tyres and the road surface wearing out is now becoming a problem.
So tell me John Dover, 50 year resident of Curtain who bought his quarter acre block for a box of matches and a song... Would you like Canberra to look something like Los Angeles in the next 50 years? Yet kids have to wear beacons and face masks as they walk to school so that the upper middle class can sit in their single occupancy AVs as they commute 50 km to work? Or somewhere where life is a bit more chill, built to a human scale, where kids can safely walk around city streets, where driving a car is not required? Somewhere like this?
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2021.12.03 00:11 stavis23 Is anyone interested in collaboration writing for a film project? My primary inspiration is Orwell’s 1984.

I’m looking to collaborate with some actual writers. Film people tend not to see literary merit in film writing, I don’t completely understand what I mean by that, it’s just a feeling of working at cross purposes when I present someone with my fragment of a story.
Anyway, the story I have in mind is tonally similar (in my imagination) to Orwell’s 1984. I love the story because we are brought into Winston’s world, and Orwell’s lucid descriptions of this fictional, totalitarian world put the reader in Winston’s shoes, in all his horror and ignorance.
Similarly, i’d like to convey attitudes like “Late Stage Capitalism” and “A Boring Dytopia” and weave these into a story about a con man and dark coming-of-age tale for his young adult niece.
Umm I guess that’s all i’d like to say, thoughts? Opinions? Thanks for reading
submitted by stavis23 to writing [link] [comments]

2021.12.03 00:11 sburgess86 Initiation of ensemble kinesin-3 motility is regulated by the rigidity of cargo-motor attachment

Initiation of ensemble kinesin-3 motility is regulated by the rigidity of cargo-motor attachment submitted by sburgess86 to BiologyPreprints [link] [comments]